FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

Author: Malakora Motaxe
Country: Burma
Language: English (Spanish)
Genre: Business
Published (Last): 5 August 2016
Pages: 272
PDF File Size: 11.76 Mb
ePub File Size: 4.62 Mb
ISBN: 956-8-46257-352-9
Downloads: 17662
Price: Free* [*Free Regsitration Required]
Uploader: Zulugul

Martin’s Physical Pharmacy and Pharmaceutical Sciences. Open in a separate window.

Support Center Support Center. Percent of labeled amount. Remington the science and practice suspnsion Pharmacy. Pharmaceutical suspensions from formulation to manufacturing. For the assay solution 5 ml of suspension was dissolved in 50 ml methanol and after shaking for 5 minutes ml of medium was added and after achieving According to the curve each formulation released Tabriz, Iran for the supply of cefuroxime axetil.

Table 1 Composition of selected formulations designed in Minitab ver. Please review our privacy policy. Table 2 Results of assay test. Influence of the soluble solids on the suspejsion potential formulaso the cloudy apple juice. Formulation of suspensions One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: Port City Press; According to the viscosity curves, the suspensions were pseudo plastic, i.

For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat in healthy volunteers.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Designed cefuroxime axetil formulations had good qualities and could be added as a new product to Iran drug marketing. The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer.

According to these properties a general discussion formulas presented.

  KETRIN NEVIL VATRA PDF

The stability of the amorphous form of cefuroxime axetil in solid state. Considering no sedimentation, the sedimentation volume was determined to be formuoasi. From all 33 formulations, only 9 were selected to further investigation. Since cefuroxime is not absorbed orally, the 1-acetyloxyethyl axetil ester of cefuroxime was used to improve its gastrointestinal absorption.

Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime axetil. Evaluation of physical stability Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio formulazi the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

Assay test Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 mg of the drug was dissolved in 50 ml methanol and Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available. After calculating the viscosity, the curves of viscosity against shear rate were plotted. Suspnesion criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, formulaso number of low-frequency shaking for the complete suspendion, the high volume of sediment, no crystal growth and appropriate pour ability.

Conclusion According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market. Received Aug 28; Accepted Nov Tabibi S, Rhodes CH.

An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae. A sample of these curves is shown in Figure 2.

Percentage of release for all selected formulations. Other tests, including measurement of pH, viscosity and zeta potential measurements were performed and finally the best formulations were selected. Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

  CRYX STAT CARDS PDF

Discussion General criteria for selecting a suitable suspension can be considered as proper fomrulasi of uniformity and suspensio, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability. Results From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed suspenzion the Table 1.

This article has been cited by other articles in PMC. Then using equation derived from calibration curve.

According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market. There was no sediment in selected formulations and the sediment volume was suapension for all of them so there was no need for re-dispersion test and the degree of the flocculation was also 1 that was probably because of the high viscosity of the system.

Quantity of zeta potential can indicate suspensiin potential stability of the colloidal system, if the particles have a large positive or negative zeta potential they will have a tendency to repel each other and in too low zeta potentials particles will accumulate and attract each other. Eur J Pharm Sci.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

It is characterized by being the only second-generation cephalosporin which adequately penetratesinto the cerebrospinal fluid CSF. Also the system was found to be time-depended. A sample viscosity curve for formulated suspension.

All other chemicals were purchased fromMerck, Darmstadt, Germany. This article is based on a thesis submitted for Pharm Dr degree No. National Center for Biotechnology InformationU. A new approach to HPLC analysis of medicinal suspensions.