hemochromatosis, and mutations in the HFE gene are associated with up to 90 .. and Prevention website. ncbddd/hemochromatosis/training/pdf/ . Hereditary hemochromatosis (HH) is a genetic disease that alters the When phlebotomy is started early in the course of the illness, it can prevent most complications. Iron Overload and Hemochromatosis FAQs []. Hemochromatosis is a condition that causes excess absorption of iron from the digestive tract. It is important to diagnose hereditary hemochromatosis early in the course of the disease because early .. ().

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Affected people with or without a known family history of hemochromatosis can be diagnosed through blood tests for iron followed by genetic testing if they are symptomatic or have complications.

What is family health history? Family history is an important risk factor for hereditary hemochromatosis. Men and women have the same chance of inheriting two copies of the altered HFE gene.

Family members share genes, behaviors, lifestyles, and environments that together may influence health and disease. July is National Hemochromatosis Awareness Month.

Secondary hemochromatosis is caused by anemia, alcoholism, and other disorders. If left untreated, this iron buildup may lead to tissue and organ damage over time. These blood tests measure how much iron is in the body.

Hereditary Hemochromatosis

When an individual inherits two altered copies of the gene—one from each parent—they are at risk of developing high iron levels which may lead to illness or organ damage over time. People who inherit an altered gene from only one parent are carriers for the disorder, but are not typically affected themselves.

Most people with hereditary hemochromatosis never develop symptoms or complications. Recommend on Facebook Tweet Share Compartir.

Hereditary Hemochromatosis | Features | CDC

However, men are more likely than women to develop complications and at an earlier age because women lose excess iron in the blood naturally during menstruation and pregnancy. Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content. For example, if you have hereditary hemochromatosis due to two altered HFE genes, then your siblings have a 1 in 4 chance of also having two altered HFE genes.


It is helpful to talk with your family members about their health history, write this information down, update it from time to time, and share it with your doctor.

If you have a family health history of hemochromatosis, talk to your doctor about testing for hereditary hemochromatosis. Symptoms of hemochromatosis include. A blood test can be used to screen people who may have hemochromatosis by measuring how much iron is in their blood.

Hereditary hemochromatosis is one of the most common genetic disorders in the United States. Hereditary hemochromatosis is more common among U. Men are more likely to develop complications and often at an earlier age. Symptoms of hemochromatosis include Feeling of tiredness or weakness, Weight loss, Joint pain, Bronze or grey skin color, Abdominal pain, and Loss of sex drive.

To learn more about family health history, visit: Too much iron is toxic to the body and over time the high levels of iron can damage tissues and organs and lead to Cirrhosis liver damageHepatocellular carcinoma liver cancerHeart problems, Arthritis joint painand Diabetes.

Early diagnosis and treatment is critical to prevent complications from the disorder. Hemochromatosis is an iron storage disorder that can cause the body to absorb too much iron from foods and other sources, such as multivitamin supplements with iron.

A useful family health history shows three generations of your biological relatives, and includes the name of the disease, age at diagnosis, or age and cause of death if relative is deceased. Hereditary hemochromatosis is caused mainly by specific inherited alterations mutations in the HFE gene.

Submit Button Past Emails. To learn more about how to collect your family health history, visit: Early symptoms, such as feeling tired or weak, are common and can cause hemochromatosis to be confused with a variety of other diseases. Features Media Sign up for Features. In the United States, the most common form of hemochromatosis in adults is hereditary hemochromatosis.

Hemochromatosis Awareness|Diseases|Resources|Genomics|CDC

If you inherit two of these variants, one from each parent, you have hereditary hemochromatosis and are at risk for developing high iron levels. People who have a close biological relative with hereditary hemochromatosis due to two altered HFE genes have a higher chance of having the altered HFE gene themselves.


Knowing your family health history can help you and your doctor understand your risk for hemochromatosis. Office of Public Health Genomics Page maintained by: Hereditary hemochromatosis is a genetic disorder that hemochromxtosis cause severe liver disease and other health problems.

Get Email Updates To receive email updates about this page, enter your email address: July 11, archived document Content source: If you are diagnosed with hemochromatosis, regularly scheduled blood removal is the most effective way to lower the amount of iron in your body.

Your doctor may also recommend Annual blood tests to check your iron levels; Liver biopsy to check for cirrhosis; Iron chelation therapy, if you cannot have blood removed, which involves medicine taken either orally or injected to lower the amount of iron in your cc Dietary changes, such as avoiding multivitamins, vitamin C supplements, and iron supplements, which can increase iron throughout your body; No alcohol use because alcohol increases the risk of liver damage ; and Steps to prevent infections, including not eating uncooked fish and shellfish and getting recommended vaccinations, including those hemochromahosis hepatitis A and B.

July 17, Content source: Two blood tests can also be used to screen people who may have iron buildup due to hereditary hemochromatosis. In the United States, about 1 in non-Hispanic whites has hereditary hemochromatosis, with lower rates among other races and ethnicities. Preventive Services Task Force recommends against routine genetic screening for hereditary hemochromatosis in the asymptomatic general population, but states that individuals with a family member, especially a sibling, who is known to have hereditary hemochromatosis should be counseled regarding genetic testing.