Learn about BYDUREON, a non-insulin treatment option for adults with type 2 diabetes available in the BYDUREON Pen. Find dosing and administration information for BYDUREON, including instructions for use. Learn about BYDUREON® BCise® including efficacy, safety, PK profile, and dosing, and available resources, including Important Safety Information.

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Exenatide should be used with caution ybdureon patients receiving oral medications that require rapid gastrointestinal absorption. If a dose is missed, administer it as soon as noticed, as long as the next regularly scheduled dose is due at least 3 days later. It may be necessary to adjust the dose of antidiabetic agents if thyroid hormones are added or discontinued.

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bydurdon Patients receiving reserpine concomitantly with antidiabetic agents, such as incretin mimetics, should be monitored for changes in glycemic control. Growth hormones, such as somatropin, may decrease insulin sensitivity, leading to glucose intolerance and loss of blood glucose control. Additionally, some renal events occurred in patients who had been experiencing nausea, vomiting, or diarrhea, with or without dehydration.

Exenatide does not impair the normal glucagon response to hypoglycemia. Other reviews pacakge that garlic may provide modest improvements in blood lipids, but few studies demonstrate decreases in blood glucose in diabetic and non-diabetic patients.

Administer twice daily, within the minute time period prior to the morning and evening meals. Patient and family education regarding hypoglycemia management is crucial; the patient and patient’s family should be instructed on how to recognize and manage pacjage symptoms of hypoglycemia.

Medicine is mixed well when it appears as an even mix that is cloudy; it is okay to see air bubbles.

Both hyperglycemia and hypoglycemia have been described in patients treated with acetazolamide. Patients receiving incretin mimetics should be closely monitored for signs indicating loss of diabetic control when therapy with a hydantoin is instituted. Nausea and vomiting due to the drug may cause transient hypovolemia, which may worsen renal function. Moderate New onset diabetes mellitus, exacerbation of diabetes mellitus, and hyperglycemia due to insulin resistance have been reported with use of protease inhibitors.


Clonidine does not appear to impair recovery from hypoglycemia, and has not been found to impair glucose tolerance in diabetic patients. A selective beta-blocker may be preferred in patients with diabetes mellitus, if appropriate for the patient’s condition. Similar absorption is achieved with subcutaneous administration of exenatide in the abdomen, thigh, or arm.

bydkreon Moderate Hyperglycemia and hypoglycemia have been reported in patients treated concomitantly with quinolones and antidiabetic agents. Because of this, a potential pharmacodynamic interaction exists between thiazide diuretics and antidiabetic agents. In patients with ESRD receiving dialysis, exenatide was poorly tolerated due to gastrointestinal side effects nausea, vomiting, diarrhea.

Angiotensin II receptor antagonists: Dosage adjustments of insulin may be necessary. Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: Ethinyl Estradiol; Norethindrone; Ferrous fumarate: Hypoglycemia, sometimes resulting in coma, can occur.

Exenatide does not increase insulin activity in nondiabetics. Finally, both thiazides and sulfonylureas have been reported to cause photosensitivity reactions; bydueeon use may increase the risk of photosensitivity. Dosage adjustments of anti-diabetic medications should be considered.

Combined use with prandial insulin has not been studied and cannot be recommended. The mean apparent clearance of exenatide in humans is 9. Following a single subcutaneous injection, exenatide is released from the suspension microspheres over approximately 10 weeks. A statistically significant increase in malignant thyroid C-cell tumors was observed in female rats receiving extended-release exenatide at times clinical exposure compared to controls. Minor Loop diuretics, such as bumetanide, furosemide, and torsemide, may cause hyperglycemia and glycosuria in patients with diabetes mellitus, probably due to diuretic-induced hypokalemia.

Acetaminophen; Butalbital; Caffeine; Codeine: Furthermore, tacrolimus has been implicated in causing insulin-dependent diabetes mellitus in patients after renal transplantation. The clinical effects of these competing mechanisms is not known.

Moderate Hypoglycemia, including symptomatic episodes, has been noted in post-marketing reports with linezolid in patients with diabetes mellitus receiving therapy with antidiabetic agents, such as insulin and oral hypoglycemic agents. Hypoglycemia has occurred during fluoxetine therapy.


Bydureon (exenatide) dose, indications, adverse effects, interactions from

Acetaminophen AUC, Cmax, and Tmax were not significantly changed when acetaminophen was given 1 h before exenatide injection. In mice, exenatide administered during gestation and lactation caused increased neonatal deaths at doses that approximate clinical exposures at inserr MRHD. Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted.

First-phase insulin response release of insulin within 10 minutes following a glucose load is lost in patients with type 2 diabetes. Therefore, the use of exenatide inserr not recommended in patients with severe GI disease e.

Monitor patients on antidiabetic agents for worsening glycemic control. Dose adjustment of metformin or a thiazolidinedione is not usually required when exenatide is added. Also, adrenergic medications may decrease glucose uptake by muscle cells. Early warning signs of hypoglycemia may be less obvious in patients with hypoglycemia unawareness which can be due to a long history of diabetes where deficiencies in the release or response to counter regulatory hormones existwith autonomic neuropathy, bydureonn diabetes control, or taking beta-blockers, guanethidine, or reserpine.

Fibric acid derivatives may enhance the hypoglycemic effects of antidiabetic agents through increased insulin sensitivity and decreased glucagon secretion. When possible, it may be prudent to avoid exenatide until data in human pregnancy is available. Moderate Changes in insulin sensitivity or glycemic control may occur in patients treated with androgens.

Dehydration, dialysis, kidney transplant, renal disease, renal failure, renal impairment. Regular-release injection solution Byetta multi-dose pen-injector: While still holding the autoinjector upright, unscrew the orange cap.

Aspiration is not necessary.