Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.
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Diagnosis confirmation In any subtype of FM, lesional skin polymerase chain reaction PCR based molecular testing micinosa T-cell clonality may be positive, thereby suggesting monoclonality of the infiltrating T lymphocytes. This article has been cited by other articles in PMC.
He gave a history of childhood atopic dermatitis with mild asthma but was off all medications since several years. Case Reports Case 1 A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch on the left cheek of few months duration. Controversy exists as to whether the disease is a neoplastic process or a reactive process.
Because there is a small chance mucinoas spontaneous resolution for other forms of the disease, the effect of treatment can be difficult to assess. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content. It is possible that these activated T lymphocytes may cause mucin accumulation in the affected follicles, and it is conceivable that follicular mucinosis may occur in lesions of leprosy without granulomas.
Based on clinical suspicion both were started on multi drug therapy MDT for leprosy with complete resolution of the lesions.
Mucijosa was followed-up at monthly intervals and at the end of 6 months, the lesion had cleared significantly, although not completely and the treatment was stopped.
Perifollicular and perivascular lymphocytes are typically present in all types of FM. The third case, male, aged 22 years presented with a single erythematous, hypoesthetic plaque on the forehead.
The etiology is not known. Also called follicular mucinosis Edematous and erythematous plaques of alopecia on head and neck Children: A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch on the left cheek of few months mucimosa. No granulomas were seen. On follow-up 1 month after starting MDT, that is, in Junethe hypopigmented patch was still present, but had stopped increasing in size, the follicular prominences had flattened and some regrowth of hair was seen which continued through the next month.
Accumulation of mucin, which is composed of hyaluronate and sulfated glycosaminoglycans, in the follicle results in disruption of cellular attachments and slopecia of the pilosebaceous subunit.
At this stage it is pertinent to reflect on the vagaries and mucnosa of the practice of medicine. Indomethacin 25mg orally, twice daily; monitor for gastrointestinal adverse effects, electrolytes, and creatinine.
This page was last edited on 21 Juneat No serological or imaging studies are useful for establishing the diagnosis of FM. Follow up in September 09, 3.
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Follicular mucinosis presenting as acute dermatitis with response mucinosq dapsone. Clonal FM may regress completely. It is characterised by bald patches of skin in which hair follicles are prominent.
Some treatments that have been tried with limited success include:. Discontinue therapy or consider slow titration over months or years after complete response is evident.
Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?
Alopecia mucinosa most commonly affects face, neck and scalp, but any part of the body may be affected. Mucosal surfaces, genitalia, and acral palms and soles areas are usually spared. Periodic laboratory studies i. The cause of alopecia mucinosa is unknown, but it may have something to do with circulating immune complexes and cell-mediated immunity.
FM may affect children it is very rare in infants and toddlersbut is most common in the 4th to 6th decades. The lesions of Alopecia mucinosa tend to persist for months or years and may show spontaneous clearing, however, in general the therapy for alopecia mucinosa remains nonspecific as no single agent has been shown to consistently improve this condition.
Alopecia mucinosa | DermNet NZ
Report of four cases not responsive to minocycline. If you have any concerns with your skin or its treatment, see a dermatologist for advice.
You can help Wikipedia mucinisa expanding it. Minocycline has been used aloppecia treatment of Alopecia Mucinosa, and minocycline in ROM may be the responsible for healing in case 3: She completed 6 months of MDT in Decemberat which time the lesion had cleared completely with regrowth of all hair [ Figure 1b ]. Important to note alopeciaa both these cases were not of Alopecia mucinosa, but had a clinical presentation of diffuse acute dermatitis with an incidental finding of follicular mucinosis.
Thus we recommend that in regions endemic for leprosy, such as India, children and young adults who jucinosa with single lesions on the face that show follicular mucinosis as the only pathology, be treated with standard MDT.
Rajiv Mucinosw Department of Dermatology, P. These lesions had persisted for months, had even grown in size in case 2, and not mucinoa to topical steroids and tretinoin in case 3. Koilonychia Nail clubbing behavior: Rajiv Joshi and Vinay Gopalani 1.
Based on histological findings these cannot be diagnosed as leprosy and will be considered as Alopecia mucinosa. Alopecia mucinosa is a clinic-pathological entity which presents with several erythematous papules and plaques mainly over the head and face regions with associated loss of hair and histopathological findings of follicular mucinosis affecting most of the follicles.
Abstract Three cases with single lesion of Alopecia mucinosa follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence alopeciia extended follow-up. He too responded completely within 3 months with rifampicin, ofloxacin, minocycline ROM treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year.
Nil Conflict of Interest: Skin biopsies are required for diagnosis. Follicular mucinosis as a histological finding by itself, does not denote a specific clinico-pathological entity and has been described as an incidental finding in several unrelated conditions like angiolymphoid hyperplasia,[ 56 ] familial reticuloendotheliosis,[ 7 ] spongiotic dermatitis,[ 1 ] and in diffuse papular and eczematous eruptions.
Intralesional corticosteroids—triamcinolone acetonide, 2. A detailed morphologic and immunopathologic study. Alopecia mucinosa is diagnosed by its clinical appearance and supported by histopathological findings on biopsy:.